Raymond M. Quock
Ph.D. University of Washington, 1974
Office: Johnson Tower 233B
Phone: (509) 335-5956
- Psychology 265: Biopsychological Effects of Alcohol and Other Drugs
- Honors 390: Drug Abuse - A Global Perspective
- Pharmacology of Medical Gases in Suppression of Chronic Pain
- Role of Nitric Oxide in Drug-Induced Analgesia and Anxiolysis
Hyperbaric oxygen (HBO₂) therapy has been approved by the FDA for a limited set of clinical indications, although there are clinical reports that HBO₂ therapy appears to be effective in a broader range of conditions, including several examples of chronic pain. We have demonstrated that HBO2 therapy causes relief of acute pain and gathered convincing evidence that HBO2 therapy activates central pathways that can produce long-lasting relief of neuropathic pain Nitrous oxide (N₂O, laughing gas) is a gas that is notable for its anesthetic, analgesic, anxiolytic and euphoric properties. We identified and localized in the rat brain the opioid receptor subtypes that mediate nitrous oxide analgesia, provided the first chemical evidence for N₂O-induced neuronal release of endogenous opioid peptides in rats and have implicated a regulatory role for NO in the neuronal release of endogenous opioid peptides. We have also reported that N₂O produces significant relief of anxiety in different animal models of experimental anxiety. This anxiolytic effect is independent of the analgesic effect of N₂O and appears to be mediated by benzodiazepine sites on the GABA receptor and also involve NO.
Quock, L.P., Zhang, Y., Chung, E., Ohgami, Y., Shirachi, D.Y. & Quock, R.M. (2011). The acute antinociceptive effect of HBO2 is mediated by a NO–cyclic GMP–PKG–KATP channel pathway in mice. Brain Research 1368:102-107.
Zhang, Y., Quock, L.P., Chung, E., Ohgami, Y. & Quock, R.M. (2011). Involvement of a NO-cyclic GMP-PKG pathway in nitrous oxide-induced antinociception in mice. European Journal of Pharmacology 654:249-253.
Nair, H.K., Hain, H., Quock, R.M., Chesler, E.J., Belknap, J.K. & Lariviere, W.R. (2011). Genomic loci and candidate genes underlying inflammatory nociception. Pain 152:599-606.
Carlile, E.L., Shirachi, D.Y. & Quock, R.M. (2012). An anxiolytic-like effect of hyperbaric oxygen in the mouse light/dark exploration test. Life Sciences 90:267-271.
Liu, S.L., Li, R.P., Ni, X.X., Cai, Z.Y., Zhang, R.J., Sun, X.J., Quock, R.M. & Xu, W.G. (2012) Perfluorocarbon-facilitated CNS oxygen toxicity in rats: reversal by edaravone. Brain Research 1471:56-65
Gibbons, C.R., Liu, S., Zhang, Y., Sayre, C.L., Levitch, B., Moehlmann, S., Shirachi, D.Y. & Quock, R.M. (2013). Involvement of brain opioid receptors in the antiallodynic effect of hyperbaric oxygen (HBO2) in rats with sciatic nerve crush-induced neuropathic pain. Brain Research 1537:111-116.
Heeman, J.H., Zhang, Y., Shirachi, D.Y. & Quock, R.M. (2013) Involvement of spinal cord opioid mechanisms in the acute antinociceptive effect of hyperbaric oxygen in mice. Brain Research 1540:42-47.
Kissler, J.L., Sirohi, S., Reis, D.J., Jansen, H., Quock, R.M., Smith, D.G. & Walker, B.M. The “one-two punch” of alcoholism: role of central amygdala dynorphins/kappa opioid receptors. Biological Psychiatry (in press)
Zhang, Y. Stolz, P.A., Shirachi, D.Y. & Quock, R.M. Reduced antinociceptive responsiveness to hyperbaric oxygen in opioid-tolerant mice. European Journal of Pain (in press)