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John J. Wyrick, Ph.D.
Associate ProfessorSchool of Molecular Biosciences
Washington State University
Pullman, WA 99164-4660
Email: john@wyrick.sbs.wsu.edu
Phone: 509-335-8785
Research Interests:
Cells respond to environmental or developmental signals by reprogramming the expression
of specific genes throughout their genome. We in the Wyrick lab wish to understand
the mechanisms by which this occurs. To do so, we are using DNA microarray analysis
to decipher how gene expression is regulated in the model eukaryote,
S. cerevisiae. Ongoing projects include: (1) Using DNA microarrays to
profile genome-wide mRNA levels in histone mutant strains; (2) Analysis of global
protein-DNA interactions, particularly for yeast transcription factors; (3)
Building bioinformatics software to analyze microarray data, including an online microarray
database; and (4)
Developing new functional genomic tools to investigate changes in global chromatin structure.
Click here for detailed description of current research projects
Recent Publications:
Martin, A.M., Pouchnik, D.J., Walker, J.L., and Wyrick, J.J. (2004) Redundant Roles for Histone H3 N-Terminal Lysine Residues in Subtelomeric Gene Repression in Saccharomyces cerevisiae. Genetics 167:1123-1132.Lee, T.I., Rinaldi, N.J., Robert, F., Odom, D.T., Bar-Joseph, Z., Gerger, G.K., Hannett, N.M., Harbison, C.T., Thompson, C.M., Simon, I., Zeitlinger, J., Jennings, E.G., Murray, H.L., Gordon, D.B., Ren, B., Wyrick, J.J., Tagne, J.B., Volkert, T.L., Fraenkel, E., Gifford, D.K., Young, R.A. (2002) Transcriptional Regulatory Networks in Saccharomyces cerevisiae. Science 298: 799-804.
Wyrick, J.J. and Young, R.A. (2002) Deciphering Gene Expression Regulatory Networks. Curr Opin Genet Dev 12: 130-6.
Wyrick, J.J., Aparicio, J.G., Chen, T., Barnett, J.D., Jennings, E.G., Young, R.A., Bell, S.P., and Aparicio, O.M. (2001) Genome-Wide Distribution of ORC and MCM proteins in S. cerevisiae: High-Resolution Mapping of Replication Origins. Science 294: 2357-2360.
Click here for all Wyrick lab Publications
MBios 503 lecture notes:
Click here for lecture 3Click here for lecture 4