Introduction to Population Genetics (BIOL 519/GENE 505)
Fall 2012
Dr. Richard Gomulkiewicz

Lecture	Date	Topics covered	Outline pages	Materials
1	Aug. 21	Introduction Hardy-Weinberg world Asexual inheritance	I-1 to I-3	Syllabus Sample Critique Notes I-1 to I-7 Fun Facts about discrete random variables and logs
2	Aug. 23	Haploid & Diploid Hardy-Weinberg Sex differences	I-3 to I-6	Handouts I.1 & I.2
3	Aug. 28	Sex linkage Multilocus genotypes Linkage disequilibrium	I-6 to I-9	Handout I.3 Notes I-8 to I-11
4	Aug. 30	Recombination Interpreting D	I-9 to I-11	Handout I.4 Notes I-12 to I-16
5	Sep. 4	More about D Statistics Estimation	I-11 to I-13	Homework 1 Gamete Frequencies
6	Sep. 6	Maximum likelihood Hypothesis testing Mini-discussion 1: Hedrick pp. 98-107 & problem #13, p. 108	I-13 to I-15
7	Sep. 11	Likelihood ratio test Non-random mating Wahlund effect	I-15 to I-16 II-1 to II-2	Notes II-1 to II-6
8	Sep. 13	Wahlund effect Inbreeding	II-2 to II-6	Notes II-7 to II-9
9	Sep. 18	Homework 1 due Inbreeding coefficients F statistics	II-6 to II-8	Notes II-10 to II-17
10	Sep. 20	Intepreting F statistics Random genetic drift	II-8 to II-10	Handout II.1
11	Sep. 25	Random genetic drift	II-10 to II-14	Homework 1 key
12	Sep. 27	Bottlenecks Effective Population size Mutation	II-14 to II-17 III-1 to III-2	Notes III-1 to III-6 Notes III-7 to III-10
13	Oct. 2	Mutation Mini-discussion 2: Hedrick pp. 205-237 & problems 6, 8, 9, p. 245	III-2 to III-5	Homework 2
14	Oct. 4	Mutation & drift The coalescent	III-5 to III-7
15	Oct. 9	The coalescent	III-7 to III-10	Notes IV-1 to IV-3 Notes IV-4 to IV-7
16	Oct. 11	Selection	IV-1 to IV-3
17	Oct. 16	Diploid selection Homework #2 due	IV-4 to IV-6	Leffler et al. reading
18	Oct. 18	Over- & Underdominance	IV-7 to IV-9	Notes IV-8 to IV-12 Notes IV-13 to IV-17
19	Oct. 23	Stability analysis of over- & underdominance Mini-discussion 3: Leffler et al. 2012. PLoS Biology 10:e1001388	IV-10 to IV-12	Notes IV-A to IV-B Excel Demo Notes IV-18 to IV-21
20	Oct. 25	Multilocus selection Genetic hitchhiking Wright's adaptive topography Fisher's Fundamental Theorem	IV-A to IV-B IV-13 to IV-17	Homework 3
21	Oct. 30	Simulating selection Mutation & selection	IV-18 to 23	Homework #2 Key Notes IV-22 to IV-24 Notes IV-25 to IV-27
22	Nov. 1	mutational load inbreeding depression selection & drift	IV 24 to IV-27	Notes for inbreeding depression Notes V-1 to V-4 Last day for approval of presentation topic
23	Nov. 6	Price's Theorem	V-1 to V-4	Notes VI-1 to VI-10 Notes VI-11 to VI-16
24	Nov. 8	Migration Migration & Drift Mini-discussion 4: Hedrick pp. 569-581 & pp.587-596 and Problems #13, 15, & 17 on p. 597 Homework #3 due		Stephan article on hitchhiking vs background selection (Thanks Aaron!)
25	Nov. 13	Migration & Selection		Homework 4
26	Nov. 15	Class Cancelled		Homework #3 Key
27	Nov. 27	PRESENTATIONS Fahad Alshanbari, Mahesh Neupane, & Aaron Mahoney Ying Zhai & Weizhen Liu Tattan Hymas & Therese Jones		Alshanbari, Neupane, & Mahoney overview Zhai & Liu overview Hymas & Jones overview
28	Nov. 29	PRESENTATIONS Elizabeth Elmore, Hannah Walters, & Nevin Lawrence Rebecca Holcomb, Rachel Daniel, Megan Lewien, & Scott Carle		Holcomb, Daniel, Lewien, & Carle overview Elmore, Walters, & Lawrence overview EW&L background paper 1 EW&L background paper 2 EW&L background paper 3
29	Dec. 4	PRESENTATIONS Jayfred Godoy Scott Farnsworth & Nate Layman Nick Norton & John Bills Shiferaw Gizaw & Kebede Muleta		Gizaw & Muleta overview Farnsworth & Layman overview Godoy overview Norton & Bills overview
30	Dec. 6	PRESENTATIONS Brook Brouwer & Adam Peterson Natalie Boyle & Adam Strong ET Thornquist Homework #4 due		Boyle & Strong overview Brouwer & Peterson overview

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